I-7-Amino-3-cephem-4-carboxylic acid
Ulwazi olusisiseko:
Igama lesiNgesi:
7-ANCA;7-AMOCA;(6R,7R)-7-AMino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicAcid;7-NACA;7- NACA,7-ANCA;7-ANCAChemicalbookukungcola;CeftizoximeUkungacoceki9;CeftizoximeUkungcola16;Ceftizoximeintermediate(7-anca);7-amino-3-cephem-4-carboxylicacid
Inombolo ye-CAS: 36923-17-8
Ifomula yemolekyuli: C7H8N2O3S
Ubunzima bemolekyuli: 200.21
Inombolo ye-EINECS: 609-312-7
Ifomula yolwakhiwo:
Iindidi ezinxulumeneyo: Iziphakathi ze-Organic; abaphakathi bamayeza; Imathiriyeli ekrwada yamayeza.
Indawo yokunyibilika: 215-218°C
Indawo yokubila: 536.9±50.0 °C(Kuqikelelwe)
Ubuninzi: 1.69± 0.1g /cm3(Kuqikelelwe)
Isalathiso se-refractive: 1.735 (uqikelelo)
Indawo edanyazayo: 278.508°C
Ukunyibilika: Inyibilika kwisisombululo esinamanzi esine-asidi (incinci, ishushu), i-DMSO (incinci). Iipropati: Umgubo omhlophe okanye omhlophe wekristale.
Uxinzelelo lomphunga: 0mmHg ku-25°C
| iinkcukacha | iyunithi | umgangatho |
| Imbonakalo | Umgubo omhlophe okanye omhlophe wekristale | |
| Umxholo ophambili | % | ≥98.5% |
| Ukufuma | % | ≤1 |
| I-Mono hybrid | % | ≤0.5 |
| I-clutter epheleleyo | % | ≤1 |
I-Cephalosporin, esetyenziswa njengendawo ephakathi ye-cefbutan kunye ne-cefazoxime.
I-asidi ye-sulfuric egxininisiweyo (104.3mL, 1.92mol) yongezwa kwiibhotile ezintathu, emva koko isophthalic acid (40g, 0.24mol) yongezwa, ixutywe kwaye ishushu kwi-60 ℃, ibanjwe i-0.5h, kunye ne-60% ye-nitric acid (37.8g, 0.36) mol) yongezwa ukulawula iqondo lokukhawulezisa amathontsi. Yongeza kwiiyure ezi-2. Emva koko, ukusabela kokugcina ubushushu kwi-60 ℃ kwiiyure ezi-2. Phola ukuya ngaphantsi kwe 50 ° C, emva koko wongeze i-100mL yamanzi. Izinto eziphathekayo zipholile kwiqondo lokushisa, zithululelwe kwisihlunu, zixutywe ukuze zisuse i-asidi yenkunkuma, ikhekhe lokucoca lihlanjwe ngamanzi, lihlanjululwe ukuze lihlaziye, kwaye imveliso emhlophe yayiyi-34.6 grams, isivuno sasiyi-68.4%.
I-20Kg okanye i-25Kg / ibhakethi, ibhakethi yekhadibhodi, efakwe umaleko omhlophe kunye nengxowa emnyama ye-polyethylene. I-2℃-8℃ eyomileyo, indawo epholileyo, kude nendawo yokugcina ukukhanya, isebenza iminyaka emi-2.
