I-C50H60N5O10P cytidine, N-Benzoyl-5 -U- [i-bis (4-cyxyyl n, i-1-methythyl) phosphoramidite

I-C50h60N5O10P cytidine, n-benzoyl-5 "-e- (i-bis (4-I-1-I-1-Methylethyl) phosphoramidite]

Ulwazi olusisiseko:

Thumela i-imeyile kuthi

Iinkcukacha zemveliso

Iimpawu zeMveliso

Iinkcukacha

Inombolo yeRegistry yeCas

163759-94-2

Iipropathi eziphambili	Ixabiso	Imeko
Ubunzima bemolekyuli	I-922.01	-
pka (ubungqina)	8.59 ± 0.40	Uninzi lwe-acidic temp: 25 ° C

Amanye amagama kunye nezikhangeli

I-Canonical iyancuma

N # CCCOP (OC1C (OC (N2C = c (c (=) c1

I-Ismomeric iyancuma

C (oc [c @@ h] 1 [c @@ h] (O) (C) (C) (C) = C) = C (oc) c = c4) (c5 = cc = c (oc) c = c5) c6 = cc = c9

Intshi

I-Inchi = 1s / c50h60N5O10P / C1- 34 (2) 55-13-10) (33-18-16) 25-21-39 (59-7) (59-7) ) I-22-22-22-26-42 (60-8) 27-23-30) 64- 34 35,43-45,48h, 15,239,33h2,18h2, (H, 58,57- 48- 48- 66?

Isitshixo se-Inchi

I-Fligvmmidvdsn-GICDFOIUSA-N

Amanye amagama kule nto

I-cytidine,N-Benzoyl-5 '-O- [BIs (4-I-EAPXXYLL) phenylmethyl] -2 -O- (2-Imepuxyyteyteythl) - 5-Methyl-, 3 '- 2-Cyanothyl Bis (1-Methylethyl) phosphoramidite] (9I); 12: PN: WO03084478 iphepha: I-57 yeDNA; I-14: PN: I-US20013013036 iphepha: 17 I-DNA ifunyenwe iDNA; I-15: PN: U

S2003021160 iphepha: 19 I-DNA ifumene iDNA; 15: PN: I-US20023017 iphepha: 19 I-DNA ifunyenwe iDNA; I-16: PN: i-US200400055569 iphepha: 22 ibango leDNA; I-17: PN: i-US2000006030: 23 I-DNA; 17: PN: I-US200400140440440 Iphepha: 20 I-20 I-DNA I-DNA; 18: Pn: I-US20040014044040 I-PAG E: 20 I-DNA ye-DNA; 18: Pn: I-US20040014044048 iphepha: 20 I-DNA ye-DNA; I-18: PN: I-US2004401405050505050505054014054050 Iphepha: 20 I-DNA I-DNA; I-19: PN: U

S20030171313 iphepha: 9 I-DNA ye-DNA; I-19: PN: i-US2001398965 iphepha: 20 I-DNA ifunyenwe iDNA; I-19: PN: I-US200400055565 iphepha: 17- 22 ibango leDNA; I-19: PN: i-US20040005570 iphepha: 20 I-DNA ifunyenwe iDNA; I-19: PN: i-US2004001405 iphepha: 22 ibango leDNA; I-20: PN: i-US2004001469494996996

E: 20 Bamba iDNA; 21: PN: I-US2004000029 Page: 23 Iphepha le-DNA; 21: PN: WO03106445 Iphepha: 72 I-DNA ye-DNA; I-61: PN: i-US20030

166592 Page: 15 ibango leDNA; 7: PN: WO20055958 iphepha: 62 I-DNA ye-DNA; I-84: Pn: I-US20040171566 iphepha: 18 I-DNA ye-DNA; I-92:

I-PN: I-US20040005707 iphepha: 20 I-DNA ye-DNA; 9: PN: WO20055007825 Page: 62 I-DNA ye-DNA;NI-4-Benzoyl-2 '-O-Ethotexyl-5-O-I-Dimeethoxycyl-5-Methylcytidine-3 '-Uphomidi,NI-4-Benzoyl-2 '-O-Ethotexyl-5 '-O-I-Dimemethoxybyl-5-Methylcylididine-3 '- Amidite

Uvavanyo lwe-petctra

I-Spectra ifumaneka
I-13 c nmr
Hetero nmr

Xela kwangaphambili iipropathi

Iipropathi ezikhoyo
Ibhayimu
Ikhemikhali
Lipinski
Ulwakhiwo olunxulumene

Ibhayimu

Ipropathi	Ixabiso	Imeko	Umthombo
Into yebhayiloji	171	pl 1; Temp: 25 ° C	(1) I-ACD
Into yebhayiloji	I-1250	pl 2; Temp: 25 ° C	(1) I-ACD
Into yebhayiloji	I-47600	pH 3; Temp: 25 ° C	(1) I-ACD
Into yebhayiloji	6.44 X i-105	pH 4; Temp: 25 ° C	(1) I-ACD
Into yebhayiloji	1.00 x 106	Ph 5; Temp: 25 ° C	(1) I-ACD
Into yebhayiloji	1.00 x 106	ph 6; Temp: 25 ° C	(1) I-ACD
Into yebhayiloji	1.00 x 106	Ph 7; Temp: 25 ° C	(1) I-ACD
Into yebhayiloji	7.79 X 105	pH 8; Temp: 25 ° C	(1) I-ACD
Into yebhayiloji	1.63 x 105	PH 9; Temp: 25 ° C	(1) I-ACD
Into yebhayiloji	30800	Ph 10; Temp: 25 ° C	(1) I-ACD

Ikhemikhali

Ipropathi	Ixabiso	Imeko	Umthombo
Koc	I-106	pl 1; Temp: 25 ° C	(1) I-ACD
Koc	773	pl 2; Temp: 25 ° C	(1) I-ACD
Koc	29500	pH 3; Temp: 25 ° C	(1) I-ACD

Ipropathi	Ixabiso	Imeko	Umthombo
Koc	3.99 x 105	pH 4; Temp: 25 ° C	(1) I-ACD
Koc	8.02 X 105	Ph 5; Temp: 25 ° C	(1) I-ACD
Koc	8.70 x 105	ph 6; Temp: 25 ° C	(1) I-ACD
Koc	I-8.16 x 105	Ph 7; Temp: 25 ° C	(1) I-ACD
Koc	4.83 x 105	pH 8; Temp: 25 ° C	(1) I-ACD
Koc	1.01 X 105	PH 9; Temp: 25 ° C	(1) I-ACD
Koc	Ngo-19100	Ph 10; Temp: 25 ° C	(1) I-ACD
Ngena	4.48	pl 1; Temp: 25 ° C	(1) I-ACD
Ngena	5.34	pl 2; Temp: 25 ° C	(1) I-ACD
Ngena	6.92	pH 3; Temp: 25 ° C	(1) I-ACD
Ngena	8.06	pH 4; Temp: 25 ° C	(1) I-ACD
Ngena	8.36	Ph 5; Temp: 25 ° C	(1) I-ACD
Ngena	8.39	ph 6; Temp: 25 ° C	(1) I-ACD
Ngena	8.37	Ph 7; Temp: 25 ° C	(1) I-ACD
Ngena	8.14	pH 8; Temp: 25 ° C	(1) I-ACD
Ngena	7.46	PH 9; Temp: 25 ° C	(1) I-ACD
Ngena	6.73	Ph 10; Temp: 25 ° C	(1) I-ACD
I-LOGP	8.401 ± 0.723	Temp: 25 ° C	(1) I-ACD
I-Mass Intrinsic Solince	1.4 x 10-4 g / l	Temp: 25 ° C	(1) I-ACD
I-Mass Solity	1.1 g / l	pl 1; Temp: 25 ° C	(1) I-ACD
I-Mass Solity	I-0.16 g / l	pl 2; Temp: 25 ° C	(1) I-ACD
I-Mass Solity	4.1 x 10-3 g / l	pH 3; Temp: 25 ° C	(1) I-ACD
I-Mass Solity	I-3.0 x 10-4 g / l	pH 4; Temp: 25 ° C	(1) I-ACD
I-Mass Solity	I-1.5 x 10-4 g / l	Ph 5; Temp: 25 ° C	(1) I-ACD
I-Mass Solity	1.4 x 10-4 g / l	ph 6; Temp: 25 ° C	(1) I-ACD
I-Mass Solity	I-1.5 x 10-4 g / l	Ph 7; Temp: 25 ° C	(1) I-ACD
I-Mass Solity	I-2,5 x 10-4 g / l	pH 8; Temp: 25 ° C	(1) I-ACD
I-Mass Solity	1.2 x 10-3 g / l	PH 9; Temp: 25 ° C	(1) I-ACD
I-Mass Solity	6.3 x 10-3 g / l	Ph 10; Temp: 25 ° C	(1) I-ACD
I-Mass Solity	I-1.5 x 10-4 g / l	AMANZI AMANZI AMANZI Ph 6.97; Temp: 25 ° C	(1) I-ACD
I-Molar Intrinsic Solin	1.5 x 10-7 mol / l	Temp: 25 ° C	(1) I-ACD
I-Molar Solity	1.2 x 10-3 mol / l	pl 1; Temp: 25 ° C	(1) I-ACD

Ipropathi	Ixabiso	Imeko	Umthombo
I-Molar Solity	I-1.7 x 10-4 mol / l	pl 2; Temp: 25 ° C	(1) I-ACD
I-Molar Solity	4.4 x 10-6 mol / l	pH 3; Temp: 25 ° C	(1) I-ACD
I-Molar Solity	3.2 x 10-7 mol / l	pH 4; Temp: 25 ° C	(1) I-ACD
I-Molar Solity	1.6 x 10-7 mol / l	Ph 5; Temp: 25 ° C	(1) I-ACD
I-Molar Solity	1.5 x 10-7 mol / l	ph 6; Temp: 25 ° C	(1) I-ACD
I-Molar Solity	1.6 x 10-7 mol / l	Ph 7; Temp: 25 ° C	(1) I-ACD
I-Molar Solity	2.7 x 10-7 mol / l	pH 8; Temp: 25 ° C	(1) I-ACD
I-Molar Solity	1.3 x 10-6 mol / l	PH 9; Temp: 25 ° C	(1) I-ACD
I-Molar Solity	6.8 x 10-6 mol / l	Ph 10; Temp: 25 ° C	(1) I-ACD
I-Molar Solity	1.6 x 10-7 mol / l	AMANZI AMANZI AMANZI Ph 6.97; Temp: 25 ° C	(1) I-ACD
Ubunzima bemolekyuli	I-922.01
pka	8.59 ± 0.40	Uninzi lwe-acidic temp: 25 ° C	(1) I-ACD
pka	3.87 ± 0.20	Uninzi lwe-temp olusisiseko: i-25 ° C	(1) I-ACD

Lipinski

Ipropathi	Ixabiso	Imeko	Umthombo
I-Bonds ejikelezayo	22		(1) I-ACD
I-H Acceptors	15		(1) I-ACD
H abanikeli	1		(1) I-ACD
H umxhasi / i-acceptor sum	16		(1) I-ACD
I-LOGP	8.401 ± 0.723	Temp: 25 ° C	(1) I-ACD
Ubunzima bemolekyuli	I-922.01