IZICWANGCISO EZIQHELEKILEYO ZENKXASO YOKUGQIBELA I-NOCCEOLIDES

Intshayelelo

I-Nucleosides, iibhloko zokwakha zee-acid zenyukliya (i-DNA kunye ne-RNA), zidlale indima ebalulekileyo kuzo zonke izinto eziphilayo. Ngokulungisa ezi molekyuli, izazinzulu zivule uluhlu olukhulu lwezicelo ezinokubakho kuphando kunye namayeza. Kweli nqaku, siza kuphonononga ezinye zezicelo eziphambili zei-nucleides eguqulweyo.

Indima yeNyukoides

I-nucleostides ye-nucleostide eguqulweyo yenziwa ngokutshintsha ubume be-nucleosides yendalo, efana ne-Adenosine, Guanosine, iCytidine, kunye nomgcini. Olu hlengahlengiso lunokubandakanya utshintsho kwisiseko, iswekile, okanye zombini. Isakhiwo esitshintshileyo sinokudlulisela iipropathi ezintsha kwi-nuccoided ye-nuciecode, iyenza ilungele izicelo ezahlukeneyo.

Izicelo eziphambili

Ukuzifumanisa iziyobisi:

Iiarhente ze-anticer: i-nucleostides eguqulweyo isetyenziselwe ukuphuhlisa uluhlu lwamachiza ee-anticialr. Umzekelo, banokuyilwa ukuthintela i-DNA synthesi okanye ekujolise kuzo iiseli ezithile zomhlaza.

Iiarhente ze-antiviral: I-nucleostides eguqulweyo isetyenziselwa ukwenza amachiza a-adovilral onokuthintela ukuphindaphinda intsholongwane. Owona mzekelo ubalaseleyo kukusetyenziswa kwe-nucukides eguqulweyo kwiCovid-19 Poices.

Iiarhente ze-antibacterial: i-nycukides eguqulweyo ikwabonisa isithembiso kuphuhliso lwezinto ezintsha.

Ubunjineli bemfuza:

Ugonyo lwe-MRNA: I-Nucloostides eguqulweyo yinxalenye ebalulekileyo ye-MRNA, njengoko benokuphucula uzinzo noluzinzo lukaMnunon.

I-Antigonsensensensensensersenserse donicucootides: Ezi molekyuli, eziyilelwe ukuba zibophelele kwi-MRNA ngokulandelelana okukhethekileyo, zinokuguqulwa ukuphucula uzinzo kunye nokuchana kwazo.

Uhlobo lwemfuza: I-Nucleostides eguqulweyo inokusetyenziselwa ukwenza u-OligoUcies oLungiselweyo wezicelo zonyango, njengokulungisa isiphene semfuzo.

Izixhobo zophando:

I-NuleCleic Persies: I-Nucleostides eguqulweyo inokubandakanywa kwiindlela ezisetyenziswa kubuchule obufana ne-Fluorescence kwi-Ibridation kwi-HARGECIDE (intlanzi) kunye nohlalutyo lwe-microarray.

Ii-Aptamers: Ezi zi-Acids zinokuguqulwa zinokuguqulwa ukuba zibophelele kwiithagethi ezithile, ezinjengeeproteni okanye iimolekyuli ezincinci, kwaye zinezicelo zonyango.

Izibonelelo zeNyukliya eziguqulweyo

Ukuphuculwa kokuzinza: I-Nucleostides yeNyukoIde isungule ikwazisi ukuphucula uzinzo lwee-acid ze-nucleic, zibenza baxhathise ngakumbi ukonakaliswa zii-enzymes.

Ukonyuka kohlengahlengiso: Uhlengahlengiso lunokuphucula ubuso bendlela ye-nucleic ye-nucleid, ivumela ukujolisa ngqo kwiimolekyuli ezithile zebhayoloji.

Ukuphuculwa kweselula: I-nucukides elungisiweyo ingenzelwe ukuphucula ukukhula kwabo, ukukhulisa ukusebenza kwabo kwizicelo zonyango.

Ukuqukumbela

I-Nokia iguqulweyo ineendawo ezahlukeneyo, ukusuka ekufumaneni iziyobisi kubunjineli bemfuza. Ukusetyenziswa kwabo kakhulu kunye nokukwazi ukulungelelaniswa kwezicelo ezithilebenza izixhobo ezixabisekileyo zabaphandi kunye noogqirha. Njengoko ukuqonda kwethu kwe-nucleid chemistry kuyaqhubeka nokukhula, sinokulindela ukubona izicelo ezinobuchule ngakumbi kwi-Nucloosis eguqulweyo kwixesha elizayo.