I-nucleides eguqulweyozizinto ezibalulekileyo kwiinkalo ezahlukeneyo ze-biotechnology, amayeza, kunye nophando lwemfuzo. Ezi nycukide, ezibandakanya iziseko ezitshintshwayo, iswekile, okanye amaqela ephosphate, dlala indima ebalulekileyo kwizicelo ezinje ngemveliso ye-RNA, i-Antiviral Scopecine yemveliso. Ukufumana umthengisi othembekileyo kwi-Nucleostides eguqulweyo kubalulekile ekuqinisekiseni uphando olusemgangathweni kunye nophuhliso lwemveliso.
Eli nqaku libonisa izinto eziphambili ekufuneka ziqwalaselwe xa ukhetha umthengisi we-nucleo oselula kwaye uphakamisa uphawu olubalulekileyo ekufuneka abathengi abaphezulu mababe nalo.
1. Ukuqonda i-nucleides eguqulweyo
I-Nucleoides eguqulweyo yahlukile kwii-nucleoides zendalo ngenxa yokutshintsha kwemichiza ezikhuthaza ukuzinza kwabo, bhazulo, kunye nokusebenza. Ezinye iintlobo eziqhelekileyo zibandakanya:
• I-nuthylatey i-methylatey i-methylatey i-nuthylatey-isetyenziselwa ukomeleza uzinzo lwe-rna.
• I-nucleostides efihliweyo-isetyenziswa kunyango lwe-antiviral kunye nonyango lwe-antic.
• I-phosphoossides ye-phosphoossides-ibalulekile kwi-nucleid capepetics.
• I-Nokia ingekho semthethweni ye-nucleides-yenzelwe izicelo zobunjineli bobunjineli bobunjineli.
2. Ukuqwalaselwa okuphambili xa ukhetha umthengisi
Xa ukhangela i-nucukides eguqulweyo, ukukhetha umthengisi ohlangabezana nemigangatho ephezulu yecandelo kubalulekile. Nazi izinto ezibalulekileyo ekufuneka ziqwalaselwe:
a. Ukucoceka kunye nemigangatho esemgangathweni
I-Nokia iPhicodies ephezulu ye-Nokia kufuneka ifumane ubunyulu obungqongqo kunye nemigangatho yovavanyo lokuvavanya ukuqinisekisa ukuchaneka kwophando kunye nezicelo zamayeza. Jonga abathengisi ababonelela:
• I-HLPC okanye i-NMR yohlalutyo lweengxelo zezokungqinisisa ukucoceka.
• Ukungqinelana kwe-batch kwiziphumo zokuzala.
I-ISO okanye isiqinisekiso se-GPP samashishini alawulwayo.
b. Ukwenza ngokwezifiso kunye nezakhono zoSynthesi
Kuba izicelo ezahlukeneyo zifuna uhlengahlengiso oluthile lwe-nucleole ecaleni, umthengisi kufuneka anike iinkonzo zentshululu ezilungiselelwe iimfuno zophando. Oku kubandakanya:
• Uhlengahlengiso lwabantu ezahlukeneyo ukuze kulungele iimfuno zovavanyo.
• Imveliso ye-batch eguqukayo isusela kwi-milligrams ukuya kwimveliso enkulu.
• Ukongezwa okhethekileyo kwiqela lezicelo ekujoliswe kuzo.
c. Ukuthembeka kunye nokungaguquguquki
Ukungaguquguquki kwimigangatho kunye nomgangatho wemveliso kubalulekile kwiiprojekthi zophando zexesha elide. Umthengisi oPhezulu kufuneka enze:
Amanyathelo olawulo lomgangatho oqhelekileyo ukugcina imigangatho.
• Izithambiso zoncedo ezinzileyo ukuthintela ukuphazamiseka kophando.
• Ukuhanjiswa okuthembekileyo kunye nempahla efanelekileyo yokulawulwa kobushushu obufanelekileyo.
d. Ukuthobela umthetho kunye namaxwebhu
Abathengisi kufuneka bathobele imigangatho yemigangatho yamayeza kunye nophando. Njonga i:
• Intshukumo elungileyo yokwenza imveliso (i-GMP) yokuthotyelwa kwe-nucleostide yenqanaba le-nucleostive.
• Iphepha ledatha lokhuseleko lwenyama (i-MSDS) kunye nezatifikethi zomthetho.
• Ukusetyenziswa kophando-kuphela (ruo) okanye ukukhetha kwenqanaba lekliniki ngokusekwe kwiimfuno zesicelo.
I-3. Izibonelelo zokuSebenza nabaThengi abaPhezulu
Ukukhetha umthengisi oqinisekileyo we-nucleo osengqiqweni uqinisekisa:
• Iimveliso ezikumgangatho ophezulu kunye nezingaguqukiyo zokuchaneka koPhando.
Ukufikelela kulungiso ngokwezifiso ukuze kulungele iiprojekthi ezizodwa.
Ukuthobela imigaqo-nkqubo yezicelo zeklinikhi kunye nezorhwebo.
Ukuhanjiswa ngokufanelekileyo kunye nolawulo lwentengo yokuthintela ukulibala ukulibaziseka.
Ukuqukumbela
Ukukhetha umthengisi ofanelekileyo we-nucleoles ochanekileyo kubalulekile ekuqinisekiseni uphando ngempumelelo kunye nokusetyenziswa kwezicelo zamayeza. Ngokugxila kunyulu, ukungqinelana, ukwakha, kunye nokuthotyelwa komthetho, abaphandi kunye neengcali zeshishini banokukhusela ezona zixhobo zibalaseleyo zomsebenzi wabo. Ukutyala imali kwiNyukliya ekumgangatho ophezulu kubaboneleli abahlonelwayo kuqinisekisa ukuthembeka kunye nokuphucula ukusebenza ngempumelelo kwenzululwazi kwimihlaba efana ne-biotechnology kunye namayeza.
Ukufumana ezinye iingcebiso kunye neengcali zengcali, ndwendwela iwebhusayithi yethuhttps: //wwwchem.net/Ukuze ufunde ngakumbi malunga neemveliso zethu kunye nezisombululo.
IXESHA LOKUQALA: NgoFebwe-24 ukuya ku-2425