Sulfamethazine

I-Sulfadiazine sisithinteli-ntsholongwane se-sulfanilamide esine-antibacterial spectrum efanayo ne-sulfadiazine. Ineempembelelo ze-antibacterial kwiibhaktheriya ze-enterobacteriaceae ezifana ne-non-zymogenic Staphylococcus aureus, iStreptococcus pyogenes, iStreptococcus pneumoniae, i-Escherichia coli, i-Klebsiella, i-Salmonella, i-Shigella, njl. I-Neisseria gonorrhoea, i-Neisseria meningitidis kunye ne-Haemoenza. Nangona kunjalo, ukuchasana kwebhaktheriya kwimveliso kwanda, ngakumbi i-streptococcus, i-Neisseria kunye ne-Enterobacteriaceae bacteria. I-Sulfonamides zi-bacteriostatic agents ezibanzi, ezifanayo kwisakhiwo kwi-p-aminobenzoic acid (PABA), enokuthi isebenze ngokukhuphisana kwi-dihydrofolate synthetase kwiibhaktheriya, ngaloo ndlela ikhusela i-PABA ekusebenziseni njengezinto eziluhlaza ukwenza i-folate efunwa yibhaktheriya kunye nokunciphisa inani leentsholongwane. i-metabolism esebenzayo ye-tetrahydrofolate. Le yokugqibela yinto ebalulekileyo yokwenziwa kwe-purines, i-thymidine nucleosides kunye ne-deoxyribonucleic acid (i-DNA), ngoko inqanda ukukhula kunye nokuveliswa kwebhaktheriya.