Methyl 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate: Iipropati kunye nokusebenza

Methyl 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylatei-chemical compound kunye ne-molecular formula C9H6F2O4 kunye nenombolo ye-CAS 773873-95-3. Kwakhona kwaziwa ngama-synonyms amaninzi, njenge-methyl 2,2-difluoro-1,3-benzodioxole-5-carboxylate, i-2,2-difluorobenzodioxole-5-carboxylic acid methyl ester, kunye ne-EOS-61003. Kukwiklasi ye-heterocyclic compounds kunye ne-oxygen hetero-athomu kuphela.

Ukuqhayisa ubunyulu be-98% ubuncinci, le khompawundi yebakala leyeza lisisombululo esiguquguqukayo kumashishini afana namayeza, ii-agrochemicals, kunye nophando.Le khompawundi isetyenziswa njengeyona nto iphakathi kwi-pharmaceutical synthesis, ukudala iimveliso zokukhusela izityalo, kunye nophando lwezenzululwazi.

Kule nqaku, siza kuchaza iimpawu zemveliso eneenkcukacha kunye nokusebenza kwe-methyl 2,2-difluorobenzo [d] [1,3] dioxole-5-carboxylate, ngokusekelwe kwidatha ekhoyo.

IiPropati zoMzimba kunye nezeMichiza

I-Methyl 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate ilulwelo oluluthulu ukuya kumthubi okanye oluqinileyo, kuxhomekeke kubushushu kunye nobunyulu. Inobunzima be-molecular 216.14 g / mol kunye nobuninzi be-1.5±0.1 g / cm3. Inendawo yokubilisa ye-227.4±40.0 °C kwi-760 mmHg kunye ne-flash point ye-88.9±22.2 °C. Inomoya ophantsi woxinzelelo lwe-0.1±0.4 mmHg kwi-25 ° C kunye nokunyibilika kwamanzi okuphantsi kwe-0.31 g / L kwi-25 ° C. Ine-log yexabiso le-P ye-3.43, ebonisa ukuba i-soluble ngakumbi kwi-solvents yezinto eziphilayo kunamanzi.

Ulwakhiwo lwe-methyl 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate luquka iringi yebenzene edityaniswe neringi ye-1,3-dioxole, eneathom ezimbini zefluorine kunye neqela le-carboxylate elidityaniswe kwiringi yebenzene. . Ubukho beeathom zefluorine kwandisa ukuzinza kunye nokusebenza kwakhona kwekhompawundi, kunye ne-lipophilicity kunye ne-bioavailability. Iqela le-carboxylate linokusebenza njengeqela elishiyayo okanye i-nucleophile kwiimpendulo ezahlukeneyo. Indandatho ye-1,3-dioxole inokusebenza njenge-glycol efihliweyo okanye i-dienophile kwiimpendulo ze-cycloaddition.

Ukhuseleko kunye nokuPhathwa

I-Methyl 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate ihlelwa njengento enobungozi ngokweNkqubo yeGlobal Harmonized System of Classification and Labeling of Chemicals (GHS). Inezi nkcazo zilandelayo zengozi kunye neengxelo zokhuseleko:

• H315: Ibangela ukucaphuka kwesikhumba

• I-H319: Ibangela ukucaphuka okunzulu kwamehlo

• H335: Inokubangela ukucaphuka kokuphefumula

• P261: Kuphephe ukuphefumla uthuli/umsi/igesi/inkungu/umphunga/isitshizi

• P305+P351+P338: UKUBA EMEHLWENI: Hlanza ngononophelo ngamanzi kangangemizuzu emininzi. Susa iilensi zoqhagamshelwano, ukuba zikhona kwaye kulula ukuzenza. Qhubeka uhlamba

• P302+P352: UKUBA ULUSU: Hlamba ngesepha eninzi kunye namanzi

Amanyathelo oncedo lokuqala lwe-methyl 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate ami ngolu hlobo lulandelayo:

• Ukuphefumla: Ukuba urholile, hambisa isigulana kumoya omtsha. Ukuba ukuphefumla kunzima, nika ioksijini. Ukuba awuphefumli, nika ukuphefumla okwenziweyo. Fumana unyango

• Ukuthintana nolusu: Susa impahla engcolileyo kwaye uhlambulule ulusu kakuhle ngesepha namanzi. Ukuba uziva ungakhululekanga, funa unyango

• Ukujongana kwamehlo: Yahlula iinkophe uze uzihlambe ngamanzi abalekayo okanye ityuwa eqhelekileyo. Funa unyango olukhawulezileyo

• Ukuginya: Gcoba, musa ukugabha. Funa unyango olukhawulezileyo

Amanyathelo okukhusela umlilo we-methyl 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate ami ngolu hlobo lulandelayo:

• Into yokucima umlilo: Cima umlilo ngenkungu yamanzi, umgubo owomileyo, ugwebu okanye i-carbon dioxide yokucima into. Kuphephe ukusebenzisa amanzi abalekayo ngokuthe ngqo ukucima umlilo, nto leyo enokubangela ukutshiza kolwelo olunokutsha kwaye isasaze umlilo.

• Iingozi ezikhethekileyo: Akukho datha ikhoyo

• Amanyathelo okuthintela umlilo kunye namanyathelo okukhusela: Abacimi bomlilo kufuneka banxibe izixhobo zokuphefumla umoya, banxibe iimpahla ezigcwele umlilo, kwaye balwe nomoya ovuthuzayo. Ukuba kunokwenzeka, susa isikhongozeli emlilweni usise kwindawo evulekileyo. Izikhongozeli ezikwindawo yomlilo kufuneka zikhutshwe ngokukhawuleza ukuba ziguqulwe umbala okanye zikhupha isandi kwisixhobo sokunceda ukhuseleko. Ukwahlula indawo yengozi kwaye uthintele abasebenzi abangabalulekanga ukuba bangene. Gcina kwaye uphathe amanzi omlilo ukuthintela ukungcoliseka kwendalo

Ukuqukumbela

I-Methyl 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate ngundoqo ophakathi kwi-pharmaceutical synthesis, ukudalwa kweemveliso zokukhusela izityalo, kunye nophando lwezenzululwazi. Inesakhiwo esikhethekileyo esineeathom ezimbini ze-fluorine kunye neqela le-carboxylate elidityaniswe kwindandatho ye-benzodioxole, enika uzinzo, ukusebenza kwakhona, i-lipophilicity, kunye ne-bioavailability kwikhompawundi. Inonyibiliko oluphantsi lwamanzi kunye noxinzelelo lomphunga, kunye nendawo yokubilisa ephakathi kunye nenqaku elikhanyayo. Ihlelwa njengento enobungozi kwaye ifuna ukuphathwa ngokufanelekileyo kunye nokugcinwa. Inezicelo ezinokubakho kumashishini ahlukeneyo, afana namayeza, iikhemikhali zezolimo, uphando, kunye nabanye.

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